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Cientistas da Universidade de Utrecht, do Erasmus Medical Center e do Harbor BioMed publicaram nesta segunda-feira (4) a descoberta de um anticorpo capaz de neutralizar o Sars CoV-2, coronavírus responsável pela Covid-19. Os anticorpos são proteínas produzidas pelo próprio corpo humano capazes de reconhecer e neutralizar micro-organismos, como vírus e bactérias. Eles são produzidos pelos linfócitos B, células do sistema imunológico. São eles que lutam contra invasores como o novo coronavírus.
A equipe de pesquisadores estrangeiros já estudava
anticorpos direcionados ao Sars CoV, vírus da mesma família que causou uma epidemia
na China em 2002. E, assim, o grupo pensou em testar o de opções
descoberto também para o novo coronavírus, o Sars CoV-2, responsável pela atual
pandemia em 2020.
“É um trabalho muito preliminar. Mas é o primeiro publicado, eu sei que tem outros que estão até mais adiantados. Eles já trabalhavam com anticorpos, e tinham esse que era metade humano e metade rato. Eles imunizaram os ratos, e tinham esse de anticorpos. Adaptaram em uma versão para os humanos”, disse a pesquisadora Ana Maria Moro, do Instituto Butantan, que também pesquisa a produção de anticorpos monoclonais neutralizantes no Brasil.
De acordo com Berend-Jan Bosch, líder da pesquisa na
Universidade de Utrecht, o novo anticorpo foi capaz de neutralizar o Sars Cov-2
em células in vitro. O artigo foi publicado pela revista “Nature
Communications”. O co-autor Frank Grosveld, do Erasmus Medical Center e
diretor-científico da Harbor BioMed, disse o anticorpo é “totalmente
humano”:
“O anticorpo usado neste trabalho é ‘totalmente humano’, permite que continue mais rapidamente o desenvolvimento e reduz potenciais efeitos colaterais relacionados ao sistema imunológico”, disse Grosveld.
A detecção de anticorpos é um dos mecanismos científicos mais importantes para criação de tratamentos e vacinas contra micro-organismos. Para Ana Maria Moro, um ponto importante do estudo é que o anticorpo detectado não impede a entrada do vírus na célula.
“Fizeram um anticorpo humano, mas eles não sabem ainda como neutraliza exatamente. Isso eu achei um ponto de interrogação. E só fizeram ensaio em células de laboratório”, disse Ana Maria.
A cientista do Instituto Butantan, em São Paulo, tem um
projeto financiado pela Fundação de Amparo à Pesquisa do Estado de São Paulo
(Fapesp) que também desenvolve em laboratório anticorpos para um novo
tratamento de pacientes com a Covid-19.
Segundo ela, esta é a primeira publicação de uma
universidade sobre um anticorpo contra o Sars-CoV-2. Como tem o a
informações mais restritas, disse que uma empresa da Coreia do Sul também
conseguiu o feito em laboratório, mas sem publicação em revista científica.
“Eles identificaram uma sequência. Não quer dizer que eles tenham um produto pronto para usar. Precisa fazer estudo em macacos, precisa fazer as linhagens”, disse Ana Maria.
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